Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention?
Figure 1
(a) Meta-analysis of large randomized trials of vit E versus placebo. Meta-analysis of 7 randomized trials involving 77,031 patients comparing the risk of cardiovascular death among those randomized to placebo or vitamin E (Breslow-Day test, ). ATBC: α-Tocopherol, β-Carotene Cancer Prevention trial; CHAOS: Cambridge Heart Antioxidant Study; CI: Confidence Interval; GISSI – Gruppo Italiano per lo Studio della Sopravivenza nell’Infarto; HOPE: Heart Ourcomes Prevention Evaluation; HPS: Heart Protection Study; PPP: Primary Prevention Project, modified from [40]. (b) Meta-analysis of Randomized Trials of β-carotene versus Placebo. Meta-analysis of 6 randomized trials involving 131,551 patients comparing the risk of cardiovascular death among those randomized to placebo or β-carotene (Breslow-Day test, ). ATBC: α-Tocopherol, β-Carotene Cancer Prevention trial; CARET: β-Carotene and Retinol Efficacy Trial; HPS: Heart Protection Study; NSCP: Nambour Skin Cancer Prevention; PHS: Physicians’ Health Study; WHS: Women’s Health Study, modified from [40].
