- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
International Journal of Inflammation
Volume 2011 (2011), Article ID 569416, 5 pages
Cytotoxicity and Induction of Inflammation by Pepsin in Acid in Bronchial Epithelial Cells
1ELEGI, Colt Research Laboratories, MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH 16 4TJ, UK
2Department of Medical Microbiology, University Medical Center Utrecht, 3508 Utrecht, The Netherlands
Received 23 February 2011; Revised 17 May 2011; Accepted 20 May 2011
Academic Editor: Jean-Marc Cavaillon
Copyright © 2011 Erik Bathoorn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- J. W. Wynne, R. Ramphal, and C. I. Hood, “Tracheal mucosal damage after aspiration. A scanning electron microscope study,” American Review of Respiratory Disease, vol. 124, no. 6, pp. 728–732, 1981.
- C. Bonnans, K. Fukunaga, M. A. Levy, and B. D. Levy, “Lipoxin A4 regulates bronchial epithelial cell responses to acid injury,” American Journal of Pathology, vol. 168, no. 4, pp. 1064–1072, 2006.
- B. Beck-Schimmer, D. S. Rosenberger, S. B. Neff et al., “Pulmonary aspiration: new therapeutic approaches in the experimental model,” Anesthesiology, vol. 103, no. 3, pp. 556–566, 2005.
- N. D. Nader, B. A. Davidson, A. R. Tait, B. A. Holm, and P. R. Knight, “Serine antiproteinase administration preserves innate superoxide dismutase levels after acid aspiration and hyperoxia but does not decrease lung injury,” Anesthesia and Analgesia, vol. 101, no. 1, pp. 213–219, 2005.
- T. Nagase, N. Uozumi, S. Ishii et al., “Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2,” Nature Immunology, vol. 1, no. 1, pp. 42–45, 2000.
- B. A. Davidson, P. R. Knight, Z. Wang et al., “Surfactant alterations in acute inflammatory lung injury from aspiration of acid and gastric particulates,” American Journal of Physiology, vol. 288, no. 4, pp. L699–L708, 2005.
- T. P. Kennedy, K. J. Johnson, R. G. Kunkel, P. A. Ward, P. R. Knight, and J. S. Finch, “Acute acid aspiration lung injury in the rat: biphasic pathogenesis,” Anesthesia and Analgesia, vol. 69, no. 1, pp. 87–92, 1989.
- H. G. Folkesson, M. A. Matthay, C. A. Hebert, and V. C. Broaddus, “Acid aspiration-induced lung injury in rabbits is mediated by interleukin- 8-dependent mechanisms,” Journal of Clinical Investigation, vol. 96, no. 1, pp. 107–116, 1995.
- O. Sacco, M. Silvestri, F. Sabatini et al., “IL-8 and airway neutrophilia in children with gastroesophageal reflux and asthma-like symptoms,” Respiratory medicine, vol. 100, no. 2, pp. 307–315, 2006.
- D. W. Piper and B. H. Fenton, “pH stability and activity curves of pepsin with special reference to their clinical importance,” Gut, vol. 6, no. 5, pp. 506–508, 1965.
- K. K. Balan, A. T. Jones, N. B. Roberts, J. P. Pearson, M. Critchley, and S. A. Jenkins, “The effects of Helicobacter pylori colonization on gastric function and the incidence of portal hypertensive gastropathy in patients with cirrhosis of the liver,” American Journal of Gastroenterology, vol. 91, no. 7, pp. 1400–1406, 1996.
- N. A. Metheny, Y. H. Chang, J. S. Ye et al., “Pepsin as a marker for pulmonary aspiration,” American Journal of Critical Care, vol. 11, no. 2, pp. 150–154, 2002.
- S. Farrell, C. McMaster, D. Gibson, M. D. Shields, and W. A. McCallion, “Pepsin in bronchoalveolar lavage fluid: a specific and sensitive method of diagnosing gastro-oesophageal reflux-related pulmonary aspiration,” Journal of Pediatric Surgery, vol. 41, no. 2, pp. 289–293, 2006.
- S. Farhath, Z. H. Aghai, T. Nakhla et al., “Pepsin, a reliable marker of gastric aspiration, is frequently detected in tracheal aspirates from premature ventilated neonates: relationship with feeding and methylxanthine therapy,” Journal of Pediatric Gastroenterology and Nutrition, vol. 43, no. 3, pp. 336–341, 2006.
- R. Stovold, I. A. Forrest, P. A. Corris et al., “Pepsin, a biomarker of gastric aspiration in lung allografts: a putative association with rejection,” American Journal of Respiratory and Critical Care Medicine, vol. 175, no. 12, pp. 1298–1303, 2007.
- S. Farhath, Z. He, T. Nakhla et al., “Pepsin, a marker of gastric contents, is increased in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia,” Pediatrics, vol. 121, no. 2, pp. e253–e259, 2008.
- N. A. Tobey, S. S. Hosseini, C. Caymaz-Bor, H. R. Wyatt, G. S. Orlando, and R. C. Orlando, “The role of pepsin in acid injury to esophageal epithelium,” American Journal of Gastroenterology, vol. 96, no. 11, pp. 3062–3070, 2001.
- M. H. Oliver, N. K. Harrison, J. E. Bishop, P. J. Cole, and G. J. Laurent, “A rapid and convenient assay for counting cells cultured in microwell plates: application for assessment of growth factors,” Journal of Cell Science, vol. 92, no. 3, pp. 513–518, 1989.
- C. Casanova, J. S. Baudet, M. del Valle Velasco et al., “Increased gastro-oesophageal reflux disease in patients with severe COPD,” European Respiratory Journal, vol. 23, no. 6, pp. 841–845, 2004.
- B. Mokhlesi, A. L. Morris, C. F. Huang, A. J. Curcio, T. A. Barrett, and D. W. Kamp, “Increased prevalence of gastroesophageal reflux symptoms in patients with COPD,” Chest, vol. 119, no. 4, pp. 1043–1048, 2001.
- A. Ducolone, A. Vandevenne, H. Jouin et al., “Gastroesophageal reflux in patients with asthma and chronic bronchitis,” Allergie et Immunologie, vol. 20, no. 6, pp. 218–225, 1988.
- E. Bathoorn, J. J. W. Liesker, D. S. Postma et al., “Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation,” International Journal of COPD, vol. 4, no. 1, pp. 101–109, 2009.