Review Article

Ferritin in Adult-Onset Still’s Disease: Just a Useful Innocent Bystander?

Table 3

Hyperferritinemia in Adult-Onset Still’s Disease patient cohorts ( ).

NameYearNumber of patientsResults

Zandman-Goddard and Shoenfeld [34] (Israel)2008403 autoimmune disease patientsHyperferritinemia in 23% SLE patients, 15% dermatomyositis, 8% multiple sclerosis, 4% rheumatoid arthritis
da Costa et al. [35] (Brazil)2011150 multiple sclerosis patients8% of MS patients had hyperferritinemia
Lian et al. [36] (China)201048 AOSD patients and 86 non-AOSD patientsSignificantly higher levels of hyperferritenemia in AOSD
Fautrel et al. [37] (France)200149 AOSD and 120 control group patientsMean ferritin level was significantly higher in AOSD than in control group
Sobieska et al. [38] (Poland, Germany, Switzerland, France)199827 AOSD and 10 pediatric Still’s Disease patients.Mean ferritin level was significantly higher in AOSD than children
Schiller et al. [39] (Austria)19984 AOSD patientsAll ferritin levels >5000 ng/mL
Vignes et al. [40] (France)200014 AOSD patientsMean ferritin level was 6350 ng/mL
Uppal et al. [41] (Kuwait)200728 AOSD patientsHyperferritinemia in 89% patients
Choi et al. [42] (Korea)200317 AOSD patientsHyperferritinemia in 14 patients
Arlet et al. [43] (France)20066 AOSD patients with haemophagocytic syndromeSerum ferritin level above 10,000 ng/mL in 5 patients
Coffernils et al. [44] (Belgium)199210 AOSD patientsHyperferritinemia in 8 patients
Ota et al. [45] (Japan)19875 AOSD patients, 7 RA patientsMean ferritin levels in AOSD were 21,565 ng/mL, whereas, in RA, mean levels were 181 ng/mL
Baxevanos et al. [46] (Greece)201122 AOSD patientsHyperferritinemia in 21 patients
Akritidis et al. [47] (Greece)19979 AOSD patients8 patients had ferritin levels above 4000 ng/mL
Montecucco et al. [48] (Italy)19954 AOSD patients, 7 RA patientsAll 4 AOSD patients had hyperferritinemia and had mean ferritin greater than RA patients
Van Reeth et al. [49] (France)199420 AOSD patientsFerritin levels are higher in active AOSD than in inactive AOSD