Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis: As a Model of Crohn's Disease

Figure 1

The adoptive transfer colitis model and treatment design. For prevention studies, the mice were treated from the day they were adoptively transferred with CD4⁺CD25^- T cells and until sacrificed when the disease is fully developed (three or four weeks after transfer). For the intervention studies, the treatment was initiated at week three after adoptive transfer. The treatment was continued for two weeks until sacrificed at week five.