Cytosolic Double-Stranded DNA as a Damage-Associated Molecular Pattern Induces the Inflammatory Response in Rat Pancreatic Stellate Cells: A Plausible Mechanism for Tissue Injury-Associated Pancreatitis
Figure 3
Major histocompatibility complex (MHC) mRNA transcription is induced by synthetic double-stranded DNA (dsDNA). (a) Extracellular DNA (at 10 g/mL) stimulation has no effect on MHC class I and class II. In contrast, intracellular dsDNA (at 10 g/mL) increased expression of their transcriptional factors transporter associated with antigen processing 1 (TAP1) and low-molecular-weight protein 2 (LMP2) (b). TFx: + transfection reagent lipofectamine. *, **.
