Cytosolic Double-Stranded DNA as a Damage-Associated Molecular Pattern Induces the Inflammatory Response in Rat Pancreatic Stellate Cells: A Plausible Mechanism for Tissue Injury-Associated Pancreatitis

Figure 5

Double-stranded DNA (dsDNA) impaired cell-specific function. Cell-specific functions were impaired by intracellular dsDNA (at 1–10 𝜇g/mL) and extracellular poly (dI : dC) (at 10 𝜇g/mL) (a), (b). Intracellular dsDNA (at 10 𝜇g/mL) attenuated cell proliferation of PSCs (c)–(e). TFx: + transfection reagent lipofectamine. *𝑃<0.05, **𝑃<0.01.

(a)

(b)

(c)

(d)

(e)