Adult-Onset Still’s Disease: From Pathophysiology to Targeted Therapies
Table 1
Cytokines involved in the pathogenesis of AOSD and their potential associations with clinical/serological manifestations and disease activity. MAS: Macrophage activation syndrome, CRP: C-Reactive Protein, AOSD: Adult Onset Still’s Disease.
Cytokine
Clinical-serological associations
Tumor necrosis factor- (TNF-)
TNF- serum concentration is not associated with disease activity [8, 26]. Levels of TNF receptor (TNF-R) correlate with serum levels of CRP
Interleukin-1 (IL-1)
Potential marker for disease activity and useful for monitoring the efficacy of treatment [27, 28]