Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation

Figure 1

Schematic structures of Gab family docking proteins. Shown are the schematic domain structures of three human Gab proteins (Gab1–3), the putative human Gab4 protein, Drosophila DOS, and C. elegans SOC-1. All Gab proteins consist of a highly conserved N-terminal PH domain that is involved in membrane targeting. The central proline-rich regions mediate the association with SH3 domain-containing adaptor proteins such as Grb2. Consensus binding motifs favored by various SH2 domain-containing proteins such as SHP2, p85, Crk, and PLCγ are indicated.