Thromboangiitis Obliterans (Buerger’s Disease)—Current Practices

Table 3

Diagnostic investigation for Buerger’s disease.

Blood count
Liver function
Renal function
Fasting blood sugar
Erythrocyte sedimentation rate
C-reactive protein
Antinuclear antibodies
Rheumatoid factor
Complementary measurements
Anticentromere antibodies (for CREST)
Anti-Scl-70 antibodies (for scleroderma)
Antiphospholipid antibodies
Lipid profile
Urinalysis
Toxicology screen for cocaine and cannabis
Cryoproteins
Segmental arterial Doppler pressures
Arteriography
Echocardiography (to exclude source of emboli)
Computed tomography (to exclude potential source of emboli)
Biopsy (In proximal artery involvement or unusual locations)
Complete thrombophilia screen: proteins G and S, antithrombin III, factor V Leiden, prothrombin 20210, and homocysteinemia
Hand radiographs (to exclude calcinosis)

CREST Calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. *Adapted from [43].