Ankylosing Spondylitis: From Cells to Genes

Table 3

Association studies for ERAP1 and ankylosing spondylitis.

Population	Year	Study type	SNP	Association	Reference
UK	2007	GWAS	rs30187; rs27044; rs17482078; rs10050860; rs2287987	Risk; Risk; NS; NS; NS	[109]
Australian, British, US^1	2010	GWAS	rs27434; rs27037	Risk; Risk	[110]
UK, Australian, Canadian	2011	GWAS	rs30187	Risk	[111]
Canadian	2010	GWAS	rs30187; rs27044; rs10050860	Risk; No association; No association	[112]
Portuguese	2009	Case control	rs27044,; rs17482078; rs10050860; rs30187; rs2287987	Risk; NS; NS; Risk; NS	[113]
UK^1	2009	Case control	rs28366066; rs26653; rs2287987; rs27434; rs30187; rs10050860; rs469783; rs17482078; rs1065407; rs13167972	Protection; Risk; Protection; Risk; Risk; Protection; Risk; Protection; Protection; Protection	[114]
Canadian	2009	Case control	rs27044; rs10050860; rs30187; rs26618; rs26653; rs3734016	NS; Protection; Risk; NS; Risk; NS	[115]
Han Chinese^1	2009	Case control	rs27037; rs27980; rs27433; rs27038	Risk; Protection; Risk; Risk	[116]
Hungarian	2010	Case control	rs27044; rs17482078; rs10050860; rs30187; rs2287987	Risk; NS; Protection; NS; Protection	[117]
Korean	2010	Case control	rs27044; rs30187; rs17482078; rs10050860; rs2287987	Risk; Risk; No association; No association; No association	[118]
Han Chinese	2011	Case control	rs27038; rs27037	Risk; Risk	[119]
Han Chinese	2011	Case control	rs27044	NS	[120]
Spanish	2011	Case control	rs17481856; rs17482078; rs30187; rs2287987; rs27895; rs27044; rs26653; rs10050860	NS; Risk; Risk; Risk; NS; NS; Risk; Risk	[121]
Han Chinese	2011	Case control	rs27434,; rs27529	Risk; Risk	[122]
Iranian	2012	Case control	rs30187; rs27434; rs469876; rs13167972	Risk; Risk; NS; NS	[123]
European, Asian	2011	Meta-analysis	rs27044; rs30187	Risk; Risk	[124]
European	2011	Meta-analysis	rs17482078,; rs10050860; rs2287987	Protection; Protection; Protection
All cases	2012	Meta-analysis	rs27044; rs17482078; rs10050860; rs30187; rs2287987; rs27037	Risk; Risk; Protection; Risk; Protection; Risk	[125]

GWAS: genome-wide association study.
¹Only the SNPs associated with AS were included.
NS: not significant.