Infiltration of Proinflammatory M1 Macrophages into the Outer Retina Precedes Damage in a Mouse Model of Age-Related Macular Degeneration
Figure 3
Immune-mediated cellular infiltration and development of outer retinal lesions are specific to genetic background and pigment independent. (a) Histology of CEP-MSA albino B6 mice compared to WT BALB/c and WT B6 at the early time point. Representative images are shown (from 3–5 mice per group per experiment; two or three independent experiments were performed for each strain). INL: inner nuclear layer; ONL: outer nuclear layer; ROS: rod outer segment; RPE: retinal pigment epithelium. Images were obtained using a 63x oil objective, and the scale marker represents a 20m length. (b) Quantification shows the lack of pathology at early time points in albino B6 mice, similar to WT B6 and in contrast to WT BALB/c mice. Mean values are shown; error bars represent S.D.
