Differential Role of Rapamycin and Torin/KU63794 in Inflammatory Response of 264.7 RAW Macrophages Stimulated by CA-MRSA

Table 3

The table indicates the reduction from the control of RAW264.7 macrophages inflammatory response in the presence of 0, 0.1, 10, and 100 ng/mL Rapamycin (up) and Rapamycin and KU63794 5 ng/mL (down).

	TNF; (%-pg/mL)	IL-1; (%-pg/mL)	IL-6; (%-pg/mL)	INF; (%-pg/mL)	NO; (%-μM)
Rapamycin (ng/mL)
0	100%; 35,143 ± 4,217	100%; 496 ± 60	100%; 834 ± 100	100%; 91 ± 11	100%; 24.3 ± 2.9
0.1	120%*	113%*	120%*	102%	110%*
10	65%*	55%*	47%*	73%*	63%*
100	64%*	61%*	41%*	64%*	71%*
Rapamycin and KU63794 at 5 ng/mL
0	100%; 32,865 ± 3,944	100%; 432 ± 42	100%; 743 ± 89	100%; 95 ± 11	100%; 23.2 ± 2.8
0.1	69%*	43%*	53%*	56%*	61%*
10	53%*	38%*	48%*	44%*	54%*
100	49%*	43%*	31%*	46%*	41%*

The first line indicates the response without Rapamycin (up) or without Rapamycin and KU63794 (down) which is used as control (100% response) and the subsequent values are expressed as % of such responses.
*Indicates statistical significance (𝑃<0.05) from the control.
TNF: tumor necrosis factor, IL-1: interleukin 1, IL-6: interleukin 6, INF: interferon, and NO: nitric oxide.