Parecoxib Reduces Systemic Inflammation and Acute Lung Injury in Burned Animals with Delayed Fluid Resuscitation

Figure 1

Effect of intramuscularly administered Parecoxib on survival rate of burned animals over 48 h. Animals were divided into five groups of thirty animals per group. Animals in the burn groups were exposed to 98°C to 100°C water, scalding the back for 10 s and the abdomen for 4 s. Hartmann’s solution (40 mL/kg) was administered i.p. half at 1 h after burn and the remaining half at 8 h after burn. The burned animals were injected i.m. with saline, 0.1 mg/kg, 1.0 mg/kg, or 10 mg/kg Parecoxib at 20 min, 12 h, 24 h, and 36 h after burn. Sham animals were exposed to 24°C water and similarly injected i.m. 10 mg/kg Parecoxib as control. The survival rate of the animals was compared using Wilcoxon (Gehan) statistic.