CCR7 Receptor Expression in Mono-MAC-1 Cells: Modulation by Liver X Receptor α Activation and Prostaglandin E₂

Figure 2

PG alone and in combination with T0901317 induces functional CCR7-specific migration of MM-1 cells. Chemotaxis assays in response to 300 ng/mL CCL19 (a) or CCL21 (b) were performed in MM-1 cells stimulated for 24 h (filled black) or 48 h (filled gray) with 1 μM PG and 1 μM T0901317. The mean number of spontaneously migrating cells (that migrated to media alone) was subtracted from the number of cells that migrated in response to CCL19 or CCL21. Data represent mean ± SD of three independent experiments. , .

(a)

(b)