Review Article
Cytokines as Biomarkers and Their Respective Clinical Cutoff Levels
Figure 1
IL-12 activation of JAK-STAT pathway. IL-12 activates a series of phosphorylation events which permit STAT4 molecules to dimerize and translocate to the nucleus, upregulating a proinflammatory cascade. IL-10 has an inhibitory effect on this response transcriptionally.