Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs

Figure 6

Proposed mechanism of heme oxygenase inducer application to overcome accumulation of toxic metabolites [102, 104, 105] induced by NSAIDs. Induction of heme oxygenase by several agents [100, 101, 108] and receival of electrons via P450 [103, 105] may result in decreased formation of 20-HETE and 5-OXO-ETE toxic metabolite accumulation.