319757.fig.006a
(a)
319757.fig.006b
(b)
Figure 6: Structural model of the Pt adduct proposed to form in the reaction between d(G1C2G3A4G5C6)2 (VI) and [Pt(15NH3)2I2] (I). Context for the G3-N7/G3-N7 interstrand cross-link (a) showing nucleotides associated with different nucleic acid strands labelled by colour coded lettering. Detail (b) of the cis-[Pt(15NH3)2G3-N7,G3-N7]2+ interstrand cross-link at the tandem sheared G·A mismatch site.