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International Journal of Inorganic Chemistry
Volume 2011 (2011), Article ID 319757, 17 pages
Research Article

Insights into DNA Platination within Unusual Structural Settings

WestCHEM Department of Pure and Applied Chemistry, Thomas Graham Building, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK

Received 15 September 2011; Accepted 24 November 2011

Academic Editor: Stephen Ralph

Copyright © 2011 Stephanie Harvie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1 shows the change in 1H chemical shifts, ∆δ1H, for the assigned resonances of the aromatic protons associated with the ODN d(GCGsAGC) as a function of sample temperature. A clear melting transition occurs from duplex to single stranded form in the same way as that reported for the unsubstituted ODN d(GCGAGC) [Reference 30], indicating that the presence of phosphorothioate in the backbone does not alter the physical melting characteristics of the duplex or the tendency of the sequence to form a duplex structure containing a tandem sheared GA mismatch at the centre of the structure.

  1. Supplementary Figure