Research Article
Clinical and Microbiological Determinants of Outcome in
Staphylococcus aureus Bacteraemia
Table 1
Clinical Characteristics of 100 cases of S. aureus bacteraemia identified prospectively from 2006 to 2007.
| | Clinical Characteristics | Total | Uncomplicated | Complicated | RR | 95% CI | | | | |
| | Age | | | | | | | | Median | 65.5 | 67 | 61 | — | — | .386* | | (with IQR) | (46–78) | (42–77) | (49–78) | — | — |
| | Male Gender | 59 (%) | 40 (54.8%) | 19 (70.4%) | 1.28 | 0.94–1.50 | .096 |
| | Patient Location | | | | | | | | Admission Unit | 27(%) | 14 (19.2%) | 13 (48.1%) | 1.56 | 1.07–2.28 | .006 | | ICU | 11(%) | 10 (13.7%) | 1 (3.7%) | 0.78 | 0.62–0.98 | .280 | | Renal Unit | 19(%) | 16 (21.9%) | 3 (11.1%) | 0.84 | 0.66–1.06 | .265 | | Medical Wards | 30(%) | 25 (34.2%) | 5 (18.5%) | 0.82 | 0.65–1.03 | .148 | | Surgical Wards | 13(%) | 8 (10.9%) | 5 (18.5%) | 1.21 | 0.78–1.90 | .329 |
| | Community Acquired | 7(%) | 4 (5.5%) | 3 (11.1%) | 1.30 | 0.68–2.49 | .384 |
| | Community Onset | 33(%) | 19 (26.0%) | 14 (51.9%) | 1.40 | 1.02–1.92 | .018 |
| | Comorbidities | | | | | | | | Diabetes Mellitus | 20(%) | 10 (13.7%) | 10 (37.3%) | 1.58 | 1.00–2.48 | .021 | | IDU | 7(%) | 1 (1.4%) | 6 (22.2%) | 5.42 | 0.88–33.49 | .001 | | Smoker | 22(%) | 13 (17.8%) | 9 (33.3%) | 1.30 | 0.90–1.88 | .109 | | Excess Alcohol | 11(%) | 9 (12.3%) | 2 (7.4%) | 0.88 | 0.65–1.20 | .722 | | HIV | 0 | 0 | 0 | — | — | — | | Haemodialysis | 17(%) | 14 (19.2%) | 3 (11.1%) | 0.86 | 0.67–1.12 | .55 | | Central line in situ | 43(%) | 38 (52%) | 5 (18.5%) | 0.69 | 0.55–0.88 | .003 | | Recent Antibiotics | 26(%) | 21 (28.8%) | 5 (18.5%) | 0.87 | 0.69–1.11 | .442 | | Recent Steroid Therapy | 12(%) | 9 (12.3%) | 3 (11.1%) | 0.97 | 0.68–1.38 | 1.000 | | Recent Immunosuppression | 6(%) | 4 (5.5%) | 2 (7.4%) | 1.10 | 0.62–1.96 | .660 |
| | Management | | | | | | | | Primary Focus Removed | | | | | | | | 72 hours | 41(%) | 36 (49.3%) | 5 (18.5%) | 0.71 | 0.57–0.90 | .006 | | 72 hours/not removed | 36(%) | 22 (30.1%) | 14 (51.8%) | 1.30 | 0.98–1.74 | .061 | | Not identified | 23(%) | 15 (20.5%) | 8 (29.6%) | 1.16 | 0.83–1.60 | .423 | | Initiation of effective antibiotics ≥ 48 hours | 32 (%) | 18 (24.7%) | 14 (51.9%) | 2.10 | 1.22–3.61 | .015 | | Duration of IV treatment 2 weeks | 66(%) | 47 (64.4%) | 19 (70.4%) | 1.07 | 0.84–1.37 | .641 |
| | Outcome | | | | | | | | Mortality (all cause at 30 days) | 38/97** | 24/73 (32.9%) | 14/25** (56%) | 1.29 | 0.99–1.70 | .057 | | (39.2%) |
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P-value adjusted for ties. **two patients with complicated bacteraemia were lost to follow up at 30 days.
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