International Journal of Medicinal Chemistry

Research Article

Comparative Study on the MDR Reversal Effects of Selected Chalcones

Table 1

Substitution pattern and calculated log values of the chalcones studied for their MDR reversal activity.
530780.table.001
CompoundMethoxylation pattern of ring ARlog P Referencea
13′,4′,5′-–Cl4.0[8]
23′,4′,5′-–N(CH3)23.5[8]
33′,4′,5′-–OCH33.3[8]
42′,3′,4′-–Cl4.0[9, 10]
52′,3′,4′-–N(CH3)23.5[10]
62′,3′,4′-–OCH33.3[10]
72′,4′,6′-–Cl4.0[11]
82′,4′,6′-–N(CH3)23.5[11]
92′,4′,6′-–OCH33.3[11]
103′,4′-–Cl4.2—
113′,4′-–N(CH3)23.7[12]
123′,4′-–OCH33.4[13]
132′,4′-–Cl4.2[9]
142′,4′-–N(CH3)23.7[12, 14]
152′,4′-–OCH33.4[14]
162′,5′-–Cl4.2—
172′,5′-–N(CH3)23.7[12]
182′,5′-–OCH33.4[15]
aChalcones reported by other sources.