Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-<i>β</i>-Carboline Hydantoin and Tetrahydro-<i>β</i>-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors

<table>Synthesis of 1,3-disubstrituted tetrahydro-<i>β</i>-carbolines and tetrahydro-<i>β</i>-carboline hydantoin derived from <i>L</i>-tryptophan.</table>

International Journal of Medicinal Chemistry

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Scheme 2

Scheme 2: Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-<i>β</i>-Carboline Hydantoin and Tetrahydro-<i>β</i>-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors 

Scheme 2 | Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors 