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International Journal of Medicinal Chemistry
Volume 2011 (2011), Article ID 592879, 10 pages
http://dx.doi.org/10.1155/2011/592879
Research Article

Pharmacophore Modelling and Synthesis of Quinoline-3-Carbohydrazide as Antioxidants

1Laboratoire de Biologie Cellulaire Equipe 2SBP EA4267, 4 Place Saint Jacque 25030 Besançon Cedex, France
2Laboratoire de Chimie Thérapeutique Equipe 2SBP EA4267, 4 Place Saint Jacque 25030 Besançon Cedex, France

Received 6 October 2010; Revised 16 December 2010; Accepted 21 January 2011

Academic Editor: Armando Rossello

Copyright © 2011 Mustapha El Bakkali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

From well-known antioxidants agents, we developed a first pharmacophore model containing four common chemical features: one aromatic ring and three hydrogen bond acceptors. This model served as a template in virtual screening of Maybridge and NCI databases that resulted in selection of sixteen compounds. The selected compounds showed a good antioxidant activity measured by three chemical tests: DPPH radical, O H radical, and superoxide radical scavenging. New synthetic compounds with a good correlation with the model were prepared, and some of them presented a good antioxidant activity.