Pharmacophore Modelling and Synthesis of Quinoline-3-Carbohydrazide as Antioxidants

Table 3

Description and fit value of pharmacophore mapping of compounds 8a–h.

Compounds	R	R1	R2	R3	Fit value
8a	H	2-OH	4-OH	H	3.2
8b	H	2-OH	5-CH3	H	3.0
8c	H	2-OH	5-OCH3	H	3.3
8d	H	2-Cl	3-NO2	6-Cl	2.6
8e	CH3	2-Cl	3-NO2	6-Cl	2.8
8f	CH3	2-OH	5-CH3	H	2.7
8g	CH3	2-OH	5-OCH3	H	3.1
8h	CH3	2-NO2	H	H	2.7

Fit value represents a good match of features of the pharmacophore model with the ligand.