Table 3: Description and fit value of pharmacophore mapping of compounds 8a–h.

Compounds R R1 R2 R3 Fit value 8a H 2-OH 4-OH H 3.2 8b H 2-OH 5-CH3 H 3.0 8c H 2-OH 5-OCH3 H 3.3 8d H 2-Cl 3-NO2 6-Cl 2.6 8e CH3 2-Cl 3-NO2 6-Cl 2.8 8f CH3 2-OH 5-CH3 H 2.7 8g CH3 2-OH 5-OCH3 H 3.1 8h CH3 2-NO2 H H 2.7

Fit value represents a good match of features of the pharmacophore model with the ligand.