Table 3: Description and fit value of pharmacophore mapping of compounds 8a–h.

CompoundsRR1R2R3Fit value

8aH2-OH4-OHH3.2
8bH2-OH5-CH3H3.0
8cH2-OH5-OCH3H3.3
8dH2-Cl3-NO26-Cl2.6
8eCH32-Cl3-NO26-Cl2.8
8fCH32-OH5-CH3H2.7
8gCH32-OH5-OCH3H3.1
8hCH32-NO2HH2.7

Fit value represents a good match of features of the pharmacophore model with the ligand.