Design, Synthesis, and Antifungal Activity of New α-Aminophosphonates

Table 1

Comparison of the effect of catalysts in preparation of α-aminophosphonate by the reaction of an aldehyde, aniline and diethylphosphite.

Entry	Catalyst (0.1 mmol)	Solvent	Time (min)	Yield (%)
1	FeCl3	THF	30–120	73–84
2	CuCl2	THF	24	<5%

Compound 1: R₁  = OMe, R₂  = OH, R₃  = H; Compound 8: R₁  = Ome, R₂  = Ome, R₃  = H; Compound 11: R₁  = OMe, R₂  = OMe, R₃  = OMe; Compound 12: R₁ = H, R₂  = OMe, R₃ = H; Compound 14: R₁ = H, R₂  = H, R₃ = H; Compound 20: R₁ = H, R₂  = NO₂, R₃ = H.