Research Article
Syntheses and Biological Activity of Some Derivatives of C-9154 Antibiotic
Table 1
Synthesized C-9154 analogue and its derivatives.
| Sample code | Type | Yield (mg) | Melting point (°C) | Physical state |
| IA/01/1 | C-9154 analogue | 90% | 195-196 | White powdery solid | IA/24/1/B | Methyl ester | 160, (0.78 mmol) | 74 | Bright yellow crystalline solid | IA/21/1/B | Ethyl ester | 100, (0.46 mmol) | 63 | Light brown crystalline solid | IA/22/1/B | n-propyl ester | 170, (0.73 mmol) | 55 | Dark brown crystalline solid | IA/23/1/B | Isopropyl ester | 105, (0.45 mmol) | 70 | Dark brown crystalline solid | IA/19/1/B | n-butyl ester | 200, (0.81 mmol) | 42 | Yellow waxy solid | IA/20/1/B | 2-butyl ester | 150, (0.61 mmol) | 40 | Golden brown oil | IA/25/1/B | t-butyl ester | 2, (~0.01 mmol) | Not determined | |
|
|
The yield from the t-butyl derivative was too little and could not be optimized. This was probably due to steric hindrance from the methyl groups.
|