Syntheses and Biological Activity of Some Derivatives of C-9154 Antibiotic

Table 3

Minimum inhibitory concentration (above) and minimum bactericidal/fungicidal concentration (below) of the analogue and derivatives (μg/mL).

	IA/01/1	IA/24/1/B	IA/21/1/B	IA/22/1/B	IA/23/1/B	IA/19/1/B	IA/20/1/B	DMSO	Sparfloxacin	Fluconazole
MRSA	2.5	0.625	1.25	0.625	0.625	0.625	0.625	ND	10	ND
	10	2.5	2.5	1.25	2.5	1.25	2.5
S. aureus	2.5	0.625	0.625	0.625	0.625	0.625	0.625	ND	10	ND
	5	2.5	2.5	2.5	2.5	2.5	2.5
S. pyogenes	2.5	ND	0.625	0.625	0.625	ND	1.25	ND	10	ND
	10	ND	2.5	1.25	1.25	ND	2.5
B. subtilis	1.25	1.25	0.625	0.625	0.625	1.25	0.625	ND	5	ND
	5	5	1.25	2.5	2.5	2.5	1.25
C. ulcerans	ND	0.625	1.25	1.25	0.625	ND	1.25	ND	ND	ND
	ND	2.5	2.5	2.5	2.5	ND	5
E. coli	2.5	1.25	1.25	1.25	1.25	1.25	1.25	ND	10	ND
	5	2.5	2.5	5	5	2.5	5
P. mirabilis	2.5	1.25	1.25	1.25	1.25	0.625	1.25	ND	10	ND
	10	5	2.5	2.5	5	2.5	5
P. aeruginosa	ND	ND	ND	ND	ND	ND	ND	ND	10	ND
	ND	ND	ND	ND	ND	ND	ND
S. typhii	2.5	0.625	1.25	1.25	0.625	1.25	1.25	ND	10	ND
	5	2.5	5	2.5	2.5	2.5	5
S. dysenteriae	2.5	1.25	1.25	0.625	0.625	0.625	1.25	ND	5	ND
	10	2.5	2.5	1.25	2.5	2.5	5
K. pneumoniae	2.5	1.25	1.25	0.625	0.625	1.25	1.25	ND	5	ND
	5	5	5	2.5	2.5	2.5	2.5
C. albicans	2.5	1.25	1.25	1.25	0.625	1.25	1.25	ND	ND	25
	10	5	5	2.5	2.5	5	5
A. nigre	2.5	ND	ND	ND	ND	ND	ND	ND	ND	ND
	10	ND	ND	ND	ND	ND	ND
T. rubrum	ND	ND	ND	ND	ND	ND	ND	ND	ND	25
	ND	ND	ND	ND	ND	ND	ND

Upper values are MIC and lower values are MBC or MFC as the case may be. ND: not determined.