Aurones: A Promising Heterocyclic Scaffold for the Development of Potent Antileishmanial Agents

<table>Synthesis of chalcones <svg height="12.0625" id="M5" style="vertical-align:-0.1911pt" version="1.1" viewbox="0 0 17.125 12.0625" width="17.125" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,0,0,-.017,.062,11.763)"><path d="M58 524l-21 12q80 152 229 152q73 0 119 -41q45 -41 45 -96q0 -40 -21.5 -74.5t-62.5 -52.5q57 -20 89.5 -68.5t32.5 -109.5q0 -110 -86 -185t-214 -75q-69 0 -110.5 24.5t-41.5 65.5q0 26 18.5 43t46.5 17q45 0 96 -57q39 -43 79 -43q45 0 71.5 34t26.5 88q0 75 -49 121
q-25 23 -56 39q-34 17 -97 38v17q69 21 100 53t31 78q0 103 -99 103q-40 0 -69.5 -19t-56.5 -64z" id="x1D7D1"></path></g><g transform="matrix(.017,0,0,-.017,8.562,11.763)"><path d="M463 54l10 10l15 -21q-52 -57 -112 -57q-37 0 -55.5 15.5t-26.5 53.5q-76 -69 -159 -69q-52 0 -81 27t-29 79q0 67 67 112q48 32 201 76v68q0 49 -18.5 71t-62.5 22q-28 0 -46.5 -10t-18.5 -27q0 -10 11 -23q19 -22 19 -42q0 -26 -19 -43t-49 -17q-31 0 -48 18t-17 50
q0 59 52 92.5t139 33.5q92 0 144 -35t52 -99v-261q0 -28 21 -28q7 0 11 4zM293 97v148q-122 -35 -122 -121q0 -32 14 -49.5t38 -17.5q42 0 70 40z" id="x1D41A"></path></g>
</svg>–<svg height="12.0625" id="M6" style="vertical-align:-0.1911pt" version="1.1" viewbox="0 0 13.35 12.0625" width="13.35" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,0,0,-.017,.062,11.763)"><path d="M58 524l-21 12q80 152 229 152q73 0 119 -41q45 -41 45 -96q0 -40 -21.5 -74.5t-62.5 -52.5q57 -20 89.5 -68.5t32.5 -109.5q0 -110 -86 -185t-214 -75q-69 0 -110.5 24.5t-41.5 65.5q0 26 18.5 43t46.5 17q45 0 96 -57q39 -43 79 -43q45 0 71.5 34t26.5 88q0 75 -49 121
q-25 23 -56 39q-34 17 -97 38v17q69 21 100 53t31 78q0 103 -99 103q-40 0 -69.5 -19t-56.5 -64z" id="x1D7D1"></path></g><g transform="matrix(.017,0,0,-.017,8.562,11.763)"><path d="M256 24v-24h-240v24q51 4 51 63v500q0 61 -52 65v24h191v-589q0 -62 50 -63z" id="x1D425"></path></g>
</svg>  and of the corresponding aurones <svg height="12.0625" id="M7" style="vertical-align:-0.1911pt" version="1.1" viewbox="0 0 17.125 12.0625" width="17.125" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,0,0,-.017,.062,11.763)"><path d="M476 255v-111h-64v-144h-145v144h-248v113l313 431h80v-433h64zM60 255h208v294z" id="x1D7D2"></path></g><g transform="matrix(.017,0,0,-.017,8.562,11.763)"><path d="M463 54l10 10l15 -21q-52 -57 -112 -57q-37 0 -55.5 15.5t-26.5 53.5q-76 -69 -159 -69q-52 0 -81 27t-29 79q0 67 67 112q48 32 201 76v68q0 49 -18.5 71t-62.5 22q-28 0 -46.5 -10t-18.5 -27q0 -10 11 -23q19 -22 19 -42q0 -26 -19 -43t-49 -17q-31 0 -48 18t-17 50
q0 59 52 92.5t139 33.5q92 0 144 -35t52 -99v-261q0 -28 21 -28q7 0 11 4zM293 97v148q-122 -35 -122 -121q0 -32 14 -49.5t38 -17.5q42 0 70 40z" id="x1D41A"></path></g>
</svg>–<svg height="11.825" id="M8" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 13.35 11.825" width="13.35" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,0,0,-.017,.062,11.763)"><path d="M476 255v-111h-64v-144h-145v144h-248v113l313 431h80v-433h64zM60 255h208v294z" id="x1D7D2"></path></g><g transform="matrix(.017,0,0,-.017,8.562,11.763)"><path d="M256 24v-24h-240v24q51 4 51 63v500q0 61 -52 65v24h191v-589q0 -62 50 -63z" id="x1D425"></path></g>
</svg>.</table>

International Journal of Medicinal Chemistry

sch1

Scheme 1

Scheme 1: Aurones: A Promising Heterocyclic Scaffold for the Development of Potent Antileishmanial Agents 