Aurones: A Promising Heterocyclic Scaffold for the Development of Potent Antileishmanial Agents

Table 2

Antileishmanial activity and cytotoxicity of the synthesized aurones.

Compound	IC50 (𝜇M)		Selectivity index (SI)^a
	L. infantum intracellular amastigotes	THP1-differentiated macrophages
4a	nd^b	16.5±3.1	nd
4b	nd	8.5±0.8	nd
4c	nd	14.5±2.1	nd
4d	nd	17.5±3.1	nd
4e	4.7±0.5	54.2±7.3	11.5
4f	nd	20.5±1.2	nd
4g	5.1±0.3	62.5±1.3	12.4
4h	nd	19.6±2.5	nd
4i	1.3±0.1	75.4±4.7	57.5
4j	1.6±0.2	68.1±2.1	43.4
4k	12.2±1.4	>100	>8.2
4l	2.1±0.9	57.5±3.4	26.9
Amphotericin B	1.2±0.1	23.8±2.3	20.6

^aThe selectivity index represents the ratio of IC₅₀ on THP1-differentiated macrophages to the IC₅₀ on intracellular parasite.
^bnd: not determined, for compounds with IC₅₀ values below 20 μM on THP1-differentiated macrophages.