Development of 5-Substituted <i>N</i>-Methylmorphinan-6-ones as Potent Opioid Analgesics with Improved Side-Effect Profile

<table>Examples of clinically used opioid analgesics.</table>

International Journal of Medicinal Chemistry

Figure 1: Development of 5-Substituted <i>N</i>-Methylmorphinan-6-ones as Potent Opioid Analgesics with Improved Side-Effect Profile 