Synthesis and Anticonvulsant Activity of Various Mannich and Schiff Bases of 1,5-Benzodiazepines

Table 4

Anticonvulsant activity using thiosemicarbazide induced convulsion model.

Compound code	Thiosemicarbazide induced model			Neurotoxicity study
	0.5 hr	1 hr	2 hr	1 hr	4 hr
				Dose: 30 mg/kg
NBZD-12	30 mg	30 mg	Not protected	NN	NN
NBZD-13	30 mg	30 mg	30 mg	NN	NN
NBZD-14	30 mg	Not protected	Not protected	NN	NN
NBZD-15	30 mg	Not protected	Not protected	NN	NN
NBZD-16	30 mg	30 mg	Not protected	NN	NN
NBZD-17	30 mg	Not protected	Not protected	NN	NN
NBZD-18	30 mg	30 mg	30 mg	NN	NN
NBZD-19	30 mg	Not protected	Not protected	NN	NN
NBZD-20	30 mg	Not protected	Not protected	NN	NN
NBZD-21	30 mg	30 mg	Not protected	NN	NN
Control	—	—	—

Symbol (NN) indicates no neurotoxicity 30 mg/kg of b.w.