In Silico Inhibition Studies of Jun-Fos-DNA Complex Formation by Curcumin Derivatives

Figure 4

Binding modes of natural curcumin derivatives. (a) Curcumin sulphate (yellow), cyclocurcumin (blue), and demethoxycurcumin (green) docked to DBR of Jun-Fos complex; (b) curcumin sulphate (cyan) showing polar contacts with Arg158, Lys280, and Lys282 (magenta) (c) cyclocurcumin showing polar contacts with Arg155 and Arg158 (magenta); (d) demethoxycurcumin showing polar contacts with Arg155, Arg158, Ser276, and Arg279 (magenta).

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