Research Article

In Silico Inhibition Studies of Jun-Fos-DNA Complex Formation by Curcumin Derivatives

Figure 5

Binding modes of synthetic curcumin-based inhibitors (a) CHC011 (blue), CHC009 (green), and CHC007 (cyan) docked to DBR of Jun-Fos complex; (b) CHC011 (cyan) showing polar contacts with Arg272 and Lys282 (magenta); (c) CHC009 (cyan) showing polar contacts with Arg158 (magenta). (d) CHC007 (cyan) showing polar contacts with Arg155, Arg158, and Lys282 (magenta).
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(a)
316972.fig.005b
(b)
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(c)
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(d)