MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys

<table>Effects of MDAN-21 in individual monkeys tested in a warm-water tail-withdrawal assay of thermal nociception. Abscissae: minutes after administration of MDAN-21 (log scale). Ordinates: percent maximum possible effect (%MPE). The identification number of the monkey is shown in the upper left of each panel.</table>

International Journal of Medicinal Chemistry

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Figure 3

Figure 3: MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys 