Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N-Diethyl-Substituted Amido Moieties

Table 1

Result of general sensitivity testing with zones of inhibitory in (mm) and selectivity index.

Compd. no.	In  vitro antibacterial activity
	Organisms
	E. coli ATCC 25922		S. aureus ATCC 6538
	ZOI (mm)	SI	ZOI (mm)	SI
1	++	0.61	+	0.92
2	++	0.54	+++	2.31
3	−	—	+	0.69
4	++	0.57	++	1.08
5	++	0.57	+++	2.15
6	+++	0.86	++	1.15
7	+++	0.89	+	0.46
8	+	0.46	++	1.15
9	+	0.36	+	1.00
10	++	0.57	++	0.92
11	++	0.75	++	0.92
12	+++	0.84	++	1.00
13	+	0.43	+	1.08
14	+++	0.82	++	1.38
15	+	0.36	+	0.92
16	−	—	−	—
17	++	0.57	+++	2.23
18	+	0.29	+	1.00
19	+	0.43	++	1.08
20	++	0.54	+	1.00
21	+	0.39	+++	2.00
22	+++	0.96	+++	2.00
Str.	+++	1.00	++	1.00

+: Less active 5–12 mm; ++: moderately active 13–19 mm; +++: highly active 20–31 mm; −: resistance; str.: streptomycin clinical reference; Z.O.I.: zone of inhibition; S.I.: selective index obtained by comparing inhibition zone of compound to that of streptomycin standard; E. coli: Escherichia coli (ATCC 25922)^G−; S. aureus: Staphylococcus aureus (ATCC 6538)^G+; G−: gram negative; G+: gram positive.