Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors

Table 1

2-Oxo-3-phenylimidazolidine-1-carboxamide kinase inhibitors based on different scaffolds.

Cpd	Ar	c-Met^a; IC50 (μM)	VEGFR2^a; IC50 (μM)	TrkA^a; % inh. at 0.1 μM
1		0.02	0.01	82
2		0.03	0.01	94
3		0.05	0.15	16
4		0.03	0.23	49
5		0.31	2.50	98

^aIC₅₀ and percentage of inhibition values are reported as the average of ≥3 experiments.