Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors

Table 4

Influence of R¹ and R² substituents on the TrkA potency.

Cpd	𝐑^𝟏	𝐑^𝟐	TrkA; IC50 (nM)
5		H	4
13		H	20
14		F	3
15		H	5
16		F	2
17		F	4

^aIC₅₀ values are reported as the average of ≥2 experiments.