Research Article
Synthesis, Characterization, and Biological Evaluation of Some New Functionalized Terphenyl Derivatives
Table 2
Antifungal activity of the synthesized compounds: MIC in μg/mL (Zone of inhibition in mm).
| | Compound | Penicillium marneffei | Trichophyton mentagrophytes | Aspergillus flavus | Aspergillus fumigates | | (recultured) | (recultured) | (NCIM No. 524) | (NCIM No. 902) |
| | 3 | R | R | R | R | | 4 | R | R | R | R | | 5 | R | R | R | R | | 6 | 6.25 (8) | 6.25 (8) | 6.25 (8) | 6.25 (8) | | 7 | R | R | R | R | | 8 | 6.25 (8) | 6.25 (8) | 6.25 (8) | 6.25 (8) | | 9a | 100 (5) | 12.5 (6) | 12.5 (6) | R | | 9b | R | R | R | R | | 9c | 100 (2) | 12.5 (6) | 12.5 (6) | R | | 10a | 12.5 (6) | R | R | R | | 10b | 6.25 (8) | 6.25 (8) | 6.25 (8) | 6.25 (8) | | 10c | R | R | R | R | | 11a | 100 (4) | 12.5 (6) | 12.5 (6) | R | | 11b | 12.5 (6) | 12.5 (6) | 12.5 (6) | R | | 11c | 100 (3) | 12.5 (6) | 12.5 (6) | R | | 12 | R | R | R | R | | 13 | R | R | R | R | | 14a | R | R | R | R | | 14b | R | R | R | R | | 14c | R | R | R | R | | 15a | R | R | R | R | | 15b | R | R | R | R | | 15c | R | R | R | R | | 16 | R | R | R | R | | 17a | 12.5 (6) | 12.5 (6) | 12.5 (6) | 12.5 (6) | | 17b | R | R | R | R | | 17c | 12.5 (6) | R | R | R | | 18 | R | R | R | R | | 19 | R | 12.5 (8) | 12.5 (6) | 12.5 (8) | | Itraconozole | 6.25 (17) | 6.25 (19) | 6.25 (18) | 6.25 (18) |
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Note: R indicates fungal strains are resistant to the compounds >100 μg/mL.
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