A DFT and Semiempirical Model-Based Study of Opioid Receptor Affinity and Selectivity in a Group of Molecules with a Morphine Structural Core

Table 7

Beta coefficients and 𝑡-test for significance of coefficients in (19).

Variable	Beta coefficient	𝑡	𝑃
𝑆^𝐸12	0.90	17.53	<0.0000001
𝐹13(HOMO)	−0.24	−4.63	<0.0007
𝑆^𝑁8(LUMO+1)	−0.29	−5.70	<0.0001
𝑆^𝑁10(LUMO+1)	−0.18	−3.66	<0.0038