Syntheses and In Vitro Biological Activity of Some Derivatives of C-9154 Antibiotic

Table 1

Synthesized C-9154 analogue and its derivatives.

Sample code	Type	Yield (mg)	Melting point (°C)	Physical State
IA/12/1	C-9154 analogue	91.7%	125–127	Shiny white crystalline solid
IA/27/1/B	Methyl ester	140,; (0.64 mmol)	not determined	Colourless oil
IA/28/1/B	Ethyl ester	105,; (0.45 mmol)	79	Light yellow crystalline solid
IA/29/1/B*	n-propyl ester	170,; (0.69 mmol)	40	White crystalline solid
IA/30/1/B*	Isopropyl ester	185,; (0.75 mmol)	67	White crystalline solid
IA/31/1/B*	n-butyl ester	100,; (0.38 mmol)	not determined	Colourless oil
IA/32/1/B*	2-butyl ester	125,; (0.48 mmol)	not determined	Colourless oil

*Synthesized for the first time. Confirmed from available data and on Scifinder.