Syntheses and In Vitro Biological Activity of Some Derivatives of C-9154 Antibiotic

Table 2

Zones of inhibition (mm) of the analogue and derivatives.

	IA/12/1; (10 μg/mL)	IA/27/1/B; (5 μg/mL)	IA/28/1/B; (5 μg/mL)	IA/29/1/B; (5 μg/mL)	IA/30/1/B; (5 μg/mL)	IA/31/1/B; (5 μg/mL)	IA/32/1/B; (5 μg/mL)	DMSO	Sparfloxacin; (20 μg/mL)	fluconazole; (50 μg/mL)
MRSA	27	32	33	30	30	31	31	0	22	0
S. aureus	26	30	29	32	32	30	31	0	27	0
S. pyogenes	21	31	32	0	27	30	30	0	24	0
B. subtilis	33	37	38	34	34	31	29	0	30	0
C. ulcerans	24	0	30	32	30	0	0	0	0	0
E. coli	27	27	29	26	24	26	24	0	27	0
P. mirabilis	27	24	27	25	27	24	25	0	22	0
P. aeruginosa	0	0	0	0	0	0	0	0	20	0
S. typhii	29	27	26	27	24	27	27	0	21	0
S. dysenteriae	31	29	26	22	27	24	25	0	27	0
K. pneumoniae	30	27	25	26	24	26	25	0	25	0
C. albicans	26	22	23	20	20	22	21	0	0	24
A. nigre	21	0	0	0	0	0	0	0	0	0
T. rubrum	0	0	0	0	0	0	0	0	0	20