Syntheses and In Vitro Biological Activity of Some Derivatives of C-9154 Antibiotic

Table 3

Minimum Inhibitory Concentration (above) and Minimum Bactericidal/Fungicidal Concentration (below) of the analogue and derivatives (μg/mL).

	IA/12/1	IA/27/1/B	IA/28/1/B	IA/29/1/B	IA/30/1/B	IA/31/1/B	IA/32/1/B	DMSO	Sparfloxacin	Fluconazole
MRSA	2.5; 5	0.625; 2.5	0.625; 2.5	0.625; 5	0.625; 2.5	0.625; 2.5	0.625; 5	ND	10	ND
S. aureus	2.5; 5	0.625; 5	1.25; 5	0.625; 2.5	0.625; 2.5	0.625; 5	0.625; 2.5	ND	10	ND
S. pyogenes	2.5; 10	0.625; 2.5	0.625; 2.5	ND; ND	1.25; 5	0.625; 5	0.625; 2.5	ND	10	ND
B. subtilis	1.25; 5	0.625; 1.25	0.625; 1.25	0.625; 2.5	0.625; 2.5	0.625; 2.5	1.25; 5	ND	5	ND
C. ulcerans	2.5; 10	ND; ND	0.625; 5	0.625; 2.5	0.625; 5	ND; ND	ND; ND	ND	ND	ND
E. coli	2.5; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	ND	10	ND
P. mirabilis	2.5; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	ND	10	ND
P. aeruginosa	ND; ND	ND; ND	ND; ND	ND; ND	ND; ND	ND; ND	ND; ND	ND	10	ND
S. typhii	2.5; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	ND	10	ND
S. dysenteriae	1.25; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	ND	5	ND
K. pneumoniae	1.25; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	ND	5	ND
C. albicans	2.5; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	1.25; 5	ND	ND	25
A. nigre	2.5; 10	ND; ND	ND; ND	ND; ND	ND; ND	ND; ND	ND; ND	ND	ND	ND
T. rubrum	ND; ND	ND; ND	ND; ND	ND; ND	ND; ND	ND; ND	ND; ND	ND	ND	25

Upper values are MIC and lower values are MBC or MFC as the case may be. ND: Not Determined.