Synthesis and Anticancer Properties of Silver(I) Complexes Containing 2,6-Bis(substituted)pyridine Derivatives

Table 1

Anticancer screening of the newly synthesized ligands and Ag(I) nitrate complexes against the tested human cancer cell lines.

Compound	Cytotoxicity^a,b (IC50) (μM)
	HEPG2	A549	HT29	MCF7
1	45.11	NA	NA	NA
2	NA	NA	NA	NA
3	NA	34.55	49.82	29.5
4	1.52	1.41	1.75	3.67
5	6.12	1.08	8.85	10.72
6	1.62	3.71	52.65	3.66
Doxorubicin	4.61	3.51	5.22	2.78

^aIC₅₀, compound concentration required to inhibit tumor cell proliferation by 50%.
^bThe same experiment is carried out in triplicate.
Sample concentration range (100—0.78 μM) using MTT assay.
NA: compounds having IC₅₀ more than 60 μM.