Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones

Table 1

Reaction time and yield (%) of various compounds 3a–j and 6a–d.

Compound number	X1	X2	X3	Reaction time (h)	Yield (%) of products
3a	H	H	H	12	90
3b	Cl	H	Cl	12	92
3c	H	H	F	12	92
3d	H	H	CH3	12	95
3e	H	Cl	F	12	89
3f	H	F	H	12	90
3g	H	H	Cl	12	93
3h	H	Cl	H	12	95
3i	Cl	H	H	12	94
3j	H	H	Br	12	95
6a	H	H	H	6	96
6b	H	H	Cl	6	94
6c	H	H	CH3	6	95
6d	Cl	H	Cl	6	95