Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones

Table 2

IC₅₀ (μM) of synthesized compounds against various human cancer cell lines.

Compound number	IC50 ± SE* in μM
	PC-3; (Prostate)	MCF-7; (Breast)	IMR-32; (CNS)	Hela; (Cervix)	Hep-G2; (Liver)
3a	82.4 ± 3.5	90.6 ± 2.5	80.4 ± 3.5	>100	>100
3b	79.2 ± 3.5	80.2 ± 3	>100	>100	90.6 ± 2.5
3c	88.9 ± 2.3	>100	90.4 ± 3.5	88.8 ± 1.3	>100
3d	78.2 ± 2.4	86.2 ± 3.5	77.4 ± 3.5	>100	83.5 ± 1.2
3e	81.9 ± 2.6	83.2 ± 1.5	93.2 ± 2.5	>100	>100
3f	28.7 ± 3.3	39.6 ± 3.5	23.9 ± 2.8	15.7 ± 3.5	>100
3g	21.5 ± 2.5	23.8 ± 3.2	19.2 ± 2.3	20.4 ± 1.5	44.1 ± 2.1
3h	41.9 ± 3.5	15.5 ± 2.3	>100	28.7 ± 1.5	85.6 ± 2.2
3i	80.3 ± 1.3	54.6 ± 3.8	33.7 ± 1.2	21.8 ± 3.5	54.2 ± 2.6
3j	54.2 ± 2.5	33.4 ± 1.2	19.2 ± 2.5	88.2 ± 3.2	38.9 ± 1.1
6a	19.5 ± 2.4	>100	33.5 ± 3.3	36.1 ± 2.1	44.9 ± 3.2
6b	2.4 ± 3.4	10.7 ± 2.5	13.2 ± 2.3	7.0 ± 3.5	16.3 ± 3.5
6c	13.4 ± 1.1	11.0 ± 2.3	15.6 ± 2.1	41.9 ± 3.5	23.6 ± 2.5
6d	14.1 ± 2.2	14.6 ± 1.5	16.3 ± 1.4	>100	41.0 ± 2.3
Paclitaxel	—	0.2 ± 0.03	—	—	—
5-Fluorouracil	—	—	1.3 ± 0.01	—	0.5 ± 0.05
Mitomycin-C	1.5 ± 0.02	—	—	2.0 ± 0.03	—

*Standard error (±).