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International Journal of Medicinal Chemistry
Table of Contents
Special Issues
International Journal of Medicinal Chemistry
/
2014
/
Article
/
Tab 2
/
Research Article
Experimental Design-Based Response Surface Methodology Optimization for Synthesis of
β
-Mercapto Carbonyl Derivatives as Antimycobacterial Drugs Catalyzed by Calcium Pyrophosphate
Table 2
Experimental design and results.
Order
Coded units of variables
Reaction yield
01
+1
+1
+1
96
02
+1
+1
−1
82
03
+1
−1
+1
74
04
+1
−1
−1
68
05
−1
+1
+1
78
06
−1
+1
−1
69
07
−1
−1
+1
65
08
−1
−1
−1
57
09
−1.682
0
0
61
10
+1.682
0
0
94
11
0
−1.682
0
56
12
0
+1.682
0
93
13
0
0
−1.682
77
14
0
0
+1.682
92
15
0
0
0
94
16
0
0
0
93