Experimental Design-Based Response Surface Methodology Optimization for Synthesis of β-Mercapto Carbonyl Derivatives as Antimycobacterial Drugs Catalyzed by Calcium Pyrophosphate

Table 2

Experimental design and results.

Order	Coded units of variables			Reaction yield
	𝑋1	𝑋2	𝑋3
01	+1	+1	+1	96
02	+1	+1	−1	82
03	+1	−1	+1	74
04	+1	−1	−1	68
05	−1	+1	+1	78
06	−1	+1	−1	69
07	−1	−1	+1	65
08	−1	−1	−1	57
09	−1.682	0	0	61
10	+1.682	0	0	94
11	0	−1.682	0	56
12	0	+1.682	0	93
13	0	0	−1.682	77
14	0	0	+1.682	92
15	0	0	0	94
16	0	0	0	93