Experimental Design-Based Response Surface Methodology Optimization for Synthesis of β-Mercapto Carbonyl Derivatives as Antimycobacterial Drugs Catalyzed by Calcium Pyrophosphate
Table 3
Estimated coefficients of the model and their significances.
Source of variation
Coefficient
Sum of squares
Mean square
Significance test
93.9167
—
1
—
—
07.7982
0830.504
1
0830.504
34.87
*
09.0230
1111.880
1
1111.880
46.68
*
04.5565
0283.534
1
0283.534
11.90
*
−06.6629
0411.269
1
0411.269
17.27
*
01.3750
0015.125
1
0015.125
00.63
NS
00.3750
0001.125
1
0001.125
00.05
NS
−07.7235
0552.631
1
0552.631
23.20
*
01.1250
0010.125
1
0010.125
00.43
NS
−04.1880
0162.485
1
0162.485
06.82
*
Significant at a level of 5%; NS: not significant.
