Target Based Designing of Anthracenone Derivatives as Tubulin Polymerization Inhibiting Agents: 3D QSAR and Docking Approach

<table class="table-group" width="800px"><tr class="fig-image" id="a"><td><img alt="658016.fig.001a" src="https://static.hindawi.com/articles/ijmc/volume-2014/658016/figures/658016.fig.001a.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(a) </b>Vinblastine</td></tr></table></td></tr><tr class="fig-image" id="b"><td><img alt="658016.fig.001b" src="https://static.hindawi.com/articles/ijmc/volume-2014/658016/figures/658016.fig.001b.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(b) </b>Colchicine</td></tr></table></td></tr><tr class="fig-image" id="c"><td><img alt="658016.fig.001c" src="https://static.hindawi.com/articles/ijmc/volume-2014/658016/figures/658016.fig.001c.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(c) </b>Combretastatin A-4</td></tr></table></td></tr><tr class="fig-image" id="d"><td><img alt="658016.fig.001d" src="https://static.hindawi.com/articles/ijmc/volume-2014/658016/figures/658016.fig.001d.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(d) </b>Sulfonamide E-7010</td></tr></table></td></tr><tr class="fig-image" id="e"><td><img alt="658016.fig.001e" src="https://static.hindawi.com/articles/ijmc/volume-2014/658016/figures/658016.fig.001e.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(e) </b>Triazolyl indole T115</td></tr></table></td></tr></table>

<table>Reported tubulin interacting agents.</table>

International Journal of Medicinal Chemistry

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Figure 1

Figure 1: Target Based Designing of Anthracenone Derivatives as Tubulin Polymerization Inhibiting Agents: 3D QSAR and Docking Approach 