Nitro Derivatives of Naturally Occurring β-Asarone and Their Anticancer Activity

Scheme 1

Synthesis of 1-(2, 4, 5-trimethoxy phenyl)-2-nitropropene (1), 1-(2, 4, 5-trimethoxy phenyl)-1-nitropropene (2), and 1-(2, 4, 5-trimethoxy)phenyl-1-propanone (3). Reagents and Conditions. (a) AgNO₂, I₂, ether, room temperature 30 h; (b) NaNO₂, I₂, ethylene glycol, room temperature 48 h; (c) NaBH₄, MeOH, room temperature 30 min.